Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 26814
  Title Extrapolating beyond the data in a systematic review of spinal manipulation for nonmusculoskeletal disorders: A fall from the summit
Journal J Manipulative Physiol Ther. 2021 May;44(4):271-279
Peer Review Yes
Publication Type Article

Objective: The purpose of this article is to discuss a literature review-a recent systematic review of nonmusculoskeletal disorders-that demonstrates the potential for faulty conclusions and misguided policy implications, and to offer an alternate interpretation of the data using present models and criteria.

Methods: We participated in a chiropractic meeting (Global Summit) that aimed to perform a systematic review of the literature on the efficacy and effectiveness of mobilization or spinal manipulative therapy (SMT) for the primary, secondary, and tertiary prevention and treatment of nonmusculoskeletal disorders. After considering an early draft of the resulting manuscript, we identified points of concern and therefore declined authorship. The present article was developed to describe those concerns about the review and its conclusions.

Results: Three main concerns were identified: the inherent limitations of a systematic review of 6 articles on the topic of SMT for nonmusculoskeletal disorders, the lack of biological plausibility of collapsing 5 different disorders into a single category, and considerations for best practices when using evidence in policy-making. We propose that the following conclusion is more consistent with a review of the 6 articles. The small cadre of high- or moderate-quality randomized controlled trials reviewed in this study found either no or equivocal effects from SMT as a stand-alone treatment for infantile colic, childhood asthma, hypertension, primary dysmenorrhea, or migraine, and found no or low-quality evidence available to support other nonmusculoskeletal conditions. Therefore, further research is needed to determine if SMT may have an effect in these and other nonmusculoskeletal conditions. Until the results of such research are available, the benefits of SMT for specific or general nonmusculoskeletal disorders should not be promoted as having strong supportive evidence. Further, a lack of evidence cannot be interpreted as counterevidence, nor used as evidence of falsification or verification.

Conclusion: Based on the available evidence, some statements generated from the Summit were extrapolated beyond the data, have the potential to misrepresent the literature, and should be used with caution. Given that none of the trials included in the literature review were definitively negative, the current evidence suggests that more research on nonmusculoskeletal conditions is warranted before any definitive conclusions can be made. Governments, insurers, payers, regulators, educators, and clinicians should avoid using systematic reviews in decisions where the research is insufficient to determine the clinical appropriateness of specific care.

Author keywords: Humans; Manipulation, Spinal; Publications; Policy Making; Public Health

Author affiliations: CMG: Duke Clinical Research Institute, Duke University, Durham, North Carolina; ELH: Office of Public Health Studies, Thompson School of Social Work and Public Health, University of Hawaii at Manoa, Honolulu, Hawaii; BAM: Faculty of Health Sciences, University of Ontario Institute of Technology, Oshawa, Ontario, Canada; IDC: Health, RAND Corporation, Santa Monica, California
Corresponding author: CMG—

This abstract is reproduced with the permission of the publisher; full text is available by subscription. Click on the above link for free full text at the publisher's site. PubMed Record


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