Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 19387
  Title Is vitamin C an effective antihypertensive supplement? A review and analysis of the literature
URL http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2647059&blobtype=pdf
Journal J Chiropr Med. 2006 Summer;5(2):60-64
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Peer Review Yes
Publication Type Review
Abstract/Notes Objective: Hypertension is a common condition with high mortality from associated diseases. Epidemiological evidence suggests that a dietary deficiency of vitamin C may be a risk factor for hypertension. However the literature on vitamin C interventional trials appears divided on the efficacy of vitamin C utilization clinically.

Methods: A literature search and review of published trials using vitamin C in treating patients with hypertension was undertaken. Relevant references were located using MEDLINE (1966–2005) and the bibliographies of located articles.

Results: Thirteen trials making up 14 separate groups were identified and analyzed providing a pooled population of 284 hypertensive patients (52% female), with a weighted mean age of 58.8 ± 9.5 years. Median vitamin C dose and study intervention duration was 500mg/day and 6 weeks respectively. The weighted mean baseline and post treatment systolic blood pressures across all 14 groups were 149.6 ± 11.1 and 145.7 ± 11.0 mmHg respectively. This represented a systolic blood pressure decrease of 3.9 mmHg. Seven of the 14 groups ascertained statistically significant reductions (p < .05) in systolic blood pressures. However only 2 of the 14 groups found significant reductions in diastolic blood pressure. The weighted mean baseline and post treatment diastolic blood pressures across all 14 groups were 84.6 ± 4.4 and 82.5 ± 4.1 mmHg respectively. This represented a diastolic blood pressure decrease of 2.1 mmHg.

Conclusion: Vitamin C supplementation in hypertensive patients appears to possess modest effects on reducing systolic blood and diastolic blood pressure.

This abstract is reproduced with the permission of the publisher; click on the above link for free full text.
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