Index to Chiropractic Literature
Index to Chiropractic Literature
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ID 20116
  Title Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials
URL http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2682928&blobtype=pdf
Journal J Chiropr Med. 2008 Jun;7(2): 48-58
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Peer Review Yes
Publication Type Article
Abstract/Notes Objective: Vitamin C has been shown to be an effective therapeutic for reducing total serum cholesterol, but epidemiologic studies have determined that low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are actually better predictive measures of coronary heart disease risk. Therefore, the purpose of this study was to provide a comprehensive meta-analysis of randomized controlled trials to investigate the effect of vitamin C supplementation on LDL and HDL cholesterol as well as triglycerides in patients with hypercholesterolemia.

Methods: Thirteen randomized controlled trials published between 1970 and June 2007 were identified using Medline and a manual search. From the 13 trials, 14 separate group populations with hypercholesterolemia and who were supplemented with at least 500 mg/d of vitamin C for between 3 and 24 weeks were entered into the meta-analysis. This meta-analysis used a random-effects model; and the overall effect sizes were calculated for changes in LDL and HDL cholesterol, as well as triglyceride concentrations.

Results: The pooled estimate of effect for vitamin C supplementation on LDL and HDL cholesterol was −7.9 mg/dL (95% confidence interval [CI], −12.3 to −3.5; P = .000) and 1.1 mg/dL (95% CI, −0.2 to 2.3; not significant), respectively. The pooled estimate of effect for vitamin C supplementation on triglycerides was −20.1 mg/dL (95% CI, −33.3 to −6.8; P < .003).

Conclusion: Supplementation with at least 500 mg/d of vitamin C, for a minimum of 4 weeks, can result in a significant decrease in serum LDL cholesterol and triglyceride concentrations. However, there was a nonsignificant elevation of serum HDL cholesterol.

This abstract is reproduced with the permission of the publisher; click on the PubMed Central link above for free full text.
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