Objective: To perform a scoping review of the existing literature on salivary tests for immunoglobulin A (IgA), cortisol and C-reactive protein (CRP) to inform researchers in regards to their use as measurements of immune biomarkers following chiropractic intervention.
Methods/Results: We conducted a scoping review of existing literature available to the authors and conducted further searches and gathering of documents based on that available literature. 46 papers were gathered and included in this scoping review.
Conclusions: This is a scoping review of the existing literature on salivary tests for immunoglobulin A, cortisol and C-reactive protein. Its purpose is to inform researchers on the existing science in order to inform their use as measurements of immune biomarkers following chiropractic intervention. It is intended to inform larger projects and give that team as much background as possible in a short period of time. The results of this scoping review reveal the potential use and utility of salivary tests as measurements of immune biomarkers to explore the neuro-immuno-regulatory effects of chiropractic, adjustment and spinal manipulation.
Author keywords: Chiropractic, immunity, neuroimmunity, neuroimmunology, psychoneuroimmunology, neuroimmunoendocrine system, immune biomarkers, supersystem, vertebral subluxation, adjustment, spinal manipulation, Immunoglobulin A, C-Reactive Protein, cortisol, salivary tests
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