• Aponte BA

• Diet Therapy
• Inflammation
• Inflammation / drug therapy
• Mitochondria

Abstract: Mitochondrial functions are mainly attributed to regulation of cell proliferation, ATP synthesis, cell death, and metabolism. However, recent scientific advances reveal that mitochondria also play a central role in proinflammatory signaling, serving as a central platform for control of innate immunity and the inflammatory response. Consequently, mitochondrial dysfunctions have been related to severe chronic inflammatory disorders. Mitochondrial dysfunction can be characterized by a loss of efficiency in the electron transport chain and reductions in the synthesis of high-energy molecules, such as adenosine-5'-triphosphate (ATP) seen in aging and chronic diseases. These diseases include neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and Friedreich's ataxia; diabetes and metabolic syndrome, cardiovascular diseases, such as atherosclerosis and other heart and vascular conditions; gastrointestinal disorders; autoimmune conditions, such as multiple sclerosis, type 1 diabetes, and systemic lupus erythematosus; neurobehavioral and psychiatric diseases, such as autism spectrum disorders, bipolar and mood disorders, and schizophrenia; chronic fatigue syndrome and Gulf War illnesses; musculoskeletal diseases, such as skeletal muscle hypertrophy/atrophy and fibromyalgia; cancer; and chronic infections. 

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